For one of every hundred people, even a small amount of gluten can cause anesthesia to suffer unconscious and their health can be in serious danger.
While the domain effect of immunological reactions can be returned to them Genetic rootsMany cooperative factors include, making it difficult to map a precise series of events, which causes silic disease.
Using Transjanic rats, is an international team headed by Scientists at MacMaster University in Canada Indicated an important character The gut layer was played by many cells, which describes an important step stone that can lead to new treatment.
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Celic disease is an autoimmune disorder in a lifetime, which is active in the presence of a group of structural protein known as gluten in the intestines.
Eating anything in practice Wheat, which is made with, or rye – which means most baked goods, bread and pasta – The people of the state Temporary symptoms such as bloating, pain, diarrhea, constipation, and sometimes reflux and vomiting.
Currently, the only way to avoid symptoms is to avoid foods that mobilize them. During the long -term, dynamic immune attacks by gluten cans Damage to the small intestine guardian. These Small structures Increase the inner surface area of ​​the intestinal wall, which helps to absorb nutrients from food.
Persons with a silic disease – especially if not treated – are facing serious health risks, as is more likely The development of coloreal cancer And Cardiovascular. This disease is associated with numerous conditions, which includes only some examples AnemiaFor, for, for,. OsteoporosisFor, for, for,. Delay in growth.For, for, for,. Reproductive problemsAnd Nerve disorders.
“Today we are the only way to cure silic disease. Says MacMasters Gastric Expert Elena Wordo.
“It’s difficult to do, and experts agree that gluten -free diet is insufficient.”
About 90 90 % of people diagnosed with this condition have a pair of genes that encoded for protein HLA-DQ2.5. Of the remaining 10 %, most of the same protein is called HLA-DQ8.
Like the second type of ‘shaking’ (or Human leukemate antigen) Protein, protein falls pieces of falling attacks like Class of immune cellsTo warn other defensive tissues.
In a specific case of HLA-DQ2.5 and HLA-DQ8, protein formed to keep parts of gluten peptide that are resistant to digestion, and the killers instruct the t-cells to go hunting.
Unfortunately, these instructions are not clear to distinguish between any danger and similar content in our body, meaning that people with genes are at risk of many automatic conditions.
Not everyone However, which expresses one of the HLA-DQ2.5 or HLA-DQ8, however, will cause immune disease such as silic disease.
His , These torn pieces of gluten need to first carry across the gut wall Transport enzyme Which is tied up with peptide and changes it to ways to make it even more identifiable.
Intestinal wall cells are responsible for issuing this transport enzyme in the intestines, so they have a clear role in the early stages of the disease.
He is known too Express protein family Which is concerned with the HLA-DQ2.5 and the HLA-DQ8, which are usually regular through intestinal reactions.
What is unclear is that for people with silic disease, this staging ground actually works within pathology.
Focusing on this important link in the series, The Research team doubled the expression of large immune complexes in cells lining the intestines of people with treated and non-treated silicic disease, and in mice with human genes for HLA-DQ2.5.
He then created the functional living models of the gut, called an organized, using mouse intestinal cells, to study the expression of their immune proteins, which they are subject to inflammatory stimulations as well as forecast and intact gluten.
“This allowed us to reduce the specific purpose and effect and prove that the reaction is or not, whether and how it happens,” Says MacMasters Biosite Medical Engineer Tahid Deedar.
This made it clear that the gut lining cells were not merely inactive that they were not involved in a suicide attack in misleading efforts to relieve the body from gluten-they were key agents, offering a mesh of gluten-broken pieces of gluten broken by gut bacteria.
The presence of inflammatory microbes gives researchers a new list of targets for future treatment, which allows researchers to enjoy gluten -filled pastries without the risk of discomfort.
It was published in research Stream.
The previous version of this article was published in August 2024.
