According to a new study, regular blood giving blood is not just saving the lives of other people, according to a new study, can also improve your own blood health at genetic levels.
An international team of researchers compared 217 men’s samples who gave blood more than 100 times in their lives, from 212 men’s samples who donated less than 10 times, to find a difference in blood health.
Although differences were subtle, but frequent donors are more likely to be beneficial in a genes in the blood that says Dnmt3a. Other variants in Dnmt3a Have been The first attachment For blood cancer.
“Our job is an interesting example of how our genes interacts with the environment and as we are as old,” Says Steam Cell Biology Dominic Bonnet from the Francis Creek Institute in the UK.
In particular, the team saw blood stem cells, which produce more blood cells according to demand. As we grow older, these mechanisms can begin to break up, causing problems like blood cancer such as Cancer blood.
Anemicizing a blood loss hormone production Arthrophine. In lab tests on blood stem cells treated with Erthrophine, researchers found people who are with them Dnmt3a The mutuals created blood without mutation.
This shows that frequent anemia produces high blood cells. Research in mice shows Dnmt3a Variation after anemia stress results in a healthy blood level.
“Activities that put pressure on low levels on blood cell production allow our blood stem cells to renew and we think it likes variations that further promote stem cell growth rather than disease,” Says Bonnet.
Donating blood can better train these stem cells to better replace blood. Without introducing the potentially harmful genetic variations, follow -up tests in mice supported the idea of ​​increasing the ability to create reorganization.
However, there are some limits to consider. Blood donors are more likely to be healthy anyway (this is a condition of blood giving), so it is difficult to detect any additional health benefits, as it can be in fact a better condition to start.
“The size of our sample is quite modest, so we cannot say that the incidence of leukemic mutation before blood donations decreases,” Says Bonnet. “We will need to look at these results in large numbers.”
Regardless of any health benefits – and previous studies have found others – blood donors are in dire need. In the US, someone needs blood or platelet (small pieces in blood) In every two seconds. Having healthy blood is an extra bonus.
And when we wait for more detailed studies to confirm these results, studies tell us how blood cancer can begin first place – especially why dangerous changes do not develop in response to stress – which then refers to the potential therapy options.
“Now we are intended to work on how these variations play their role in the development of leukemia, and whether they are targeted in treatment,” Says Steam Cell Biologists Hectare Horga Incubo from the Francis Kirk Institute.
Has been published in research Blood.
