Scientists from the Packor Institute for Learning and Memory in MIT began first testing whether the sensory stimulus of the 40 -herts “gamma” frequency of the brain could cure Alzheimer’s disease in mice, with a growing idea of a growing idea of the thought. A new open access I review the article Plos Biology So far describes the state of research and now Nan Vasiv Gamma offers some basic and medical questions at the forefront of stimulation.
“As we have done all our observations, many other people in this field have published results that are very permanent.” li-huei tsaiMIT Director of Neuro Science in MIT, Packver Professor Aging brain moveAnd senior writer of the new review, with post postage Battle Park. “People have used many different ways to handle the gamma, including sensory stimulation, transcript of transmission existing stimulation, or transcript magnetic stimulation, but the key is providing stimulation to 40 Hz. They see all beneficial effects.
Discover a decade in MIT
I start with a paper Nature I 2016A series of studies led by Tasai has been developed by a series of studies showing that stimulus by 40HHz LightSound, TogetherOr Superish vibration Alzheimer’s pathology such as amyloid and tau protein reduces the properties, prevents neuron’s death, reduces synapse damage, and maintains memory and cognition in various models of Alzheimer’s mouse. Investigation of the basic mechanisms that produce these benefits have so far identified specific cellular and molecular reactions in many types of brain cells, including neuron, microogy, estecox, osteroidandosis, and brain blood vessels. Last year, for example, lab I reported Nature This 40 herits audio and visual stimulus increased the release of peptide VIP to the mice, which indicates the increased clearance of the brain through the brain’s glamorous “plumbing” system.
Meanwhile, in MIT and in MIT spin of company Cognetic treatmentClinical studies of Phase II suggest that 40Hz with Alzheimer’s lights and voice -explicit people have experienced a significant slowdown of mental atrophy and improvement of some academic measures compared to non -treatment controls. Kegano, who has also measured the main protection of the brain’s “white substance” in volunteers, has been conducting an important, nationwide phase III clinical trial of sensory gamma stimulation for more than a year.
“Neuro scientists often do this is a great time to get an ad [Alzheimer’s disease] If you are a mouse, “Park and Tasai wrote in the review.” So, our ultimate goal is to translate jeans discoveries for AD patients safe, accessible and non -Vasio Therapy. “
A growing field
As a Tasai collaboration, which includes MIT colleagues Edward Boyson And Emery Ann BrownThe results have been published, many other labs have presented the study, offering evidence that non -Vasiva Gamma can counter the pathology of Alzheimer’s pathology. Among many examples presented in the new review, a research team independently in China in 2024 Certified That 40 hits increases the flow of glymphic fluid in the sensory stimulation mice. In another instance, a team based on Harvard Medical School in 2022 Shown. This 40 herits gamma stimulation significantly reduced the burden of Tao in three of the four human volunteers using the transplant current stimulation. And i Another study In adding more than 100 people, researchers in Scotland used audio and visual gamma stimulation (37.5Hz) to improve memory memory in 2023.
Open the questions
Between the increasing number of posts explaining clinical studies with mice and clinical trials with people, there are open questions, acknowledging the Tasai and Park. The MIT team and others are still looking for cellular and molecular mechanisms that reduce the effects of jeans. Tasai says its lab is watching other neuropathy and neuromodulatory systems to better understand the trauma of sensory stimulation from a cellular response. Meanwhile, some cells, such as the microbgia, respond to the gamma stimulation and the nature of how it affects pathology is unclear.
Even despite the ongoing clinical trial of the National Phase III, it is still necessary to investigate these basic mechanisms, Social says, because the new vision about how non -Vioceo Gamma affects the brain affects the brain.
“The more we understand the mechanism, the more we understand, the more we will have good ideas about improving treatment,” says Tasai. “And the more we understand its actions and its circuits, the more we will know more than Alzheimer’s illness how it will benefit other nervous disorders.”
In fact, the review indicates the study of MIT and other organizations that provide at least some evidence that jeans can help Parkinson’s disease, stroke, anxiety, epilepsy and its academic side effects. Chemotherapy And terms that decrease MyelinLike multiple sclerosis. Tasai’s lab is studying whether she can also help down the down syndrome.
Open questions can help explain the next decade of jeans research.
